With the increasing desire to preserve natural teeth, intentional replantation has gradually become one of the alternative treatment options considered by clinicians for teeth previously deemed to be extracted. Intentional replantation involves the purposeful extraction of a tooth, followed by extraoral treatment of the tooth, and then replanting it back into its original alveolar socket. Although reported success rates vary, an increasing number of practitioners are willing to attempt intentional replantation. However, the factors to consider when selecting teeth for replantation, as well as the precautions during the replantation process, healing mechanisms, and prognosis, differ depending on the underlying pathologies, such as apical periodontitis and periodontal disease. Therefore, this review aims to briefly summarize and discuss the differences in the application of intentional replantation in teeth affected by apical periodontitis and periodontal disease.