Objective To explore the value of computed tomography (CT) combined with thromboelastography (TEG) in the evaluation of deep vein thrombosis (DVT).Methods The clinical data of 86 suspected DVT patients admitted to the Sichuan Modern Hospital from January 2021 to December 2022 were retrospectively analyzed. According to the findings of digital subtraction angiography (DSA), they were divided into a combined group of 34 cases and a non-combined group of 52 cases. CT and TEG examinations were performed in all patients, and CT values and TEG indices [R (clotting time), K (clot formation time), α angle (rate of clot formation), maximum amplitude (MA), and coagulation composite index (CI)] of the two groups were compared. The factors affecting the occurrence of DVT were determined, and the relationship of CT values and TEG indexes with DVT and their diagnostic value for DVT were analyzed.Results The R time, K time, CT values, MA and CI were different between the combined group and the non-combined group as analyzed by the t-test (P < 0.05). The R time and K time in the combined group were shorter than those in the non-combined group, and the CT values, MA and CI in the combined group were higher than those in the non-combined group. Multivariable Logistic regression analysis showed that higher CT values [O^R = 1.174, (95% CI: 1.085, 1.270) ], shorter R time [O^R = 0.194, (95% CI: 0.092, 0.409) ], shorter K time [O^R = 0.117, (95% CI: 0.037, 0.366) ], higher MA [O^R = 1.077, (95% CI: 1.021, 1.135) ] and higher CI [O^R = 47.352, (95% CI: 9.169, 244.529) ] were all risk factors for DVT (P < 0.05). Pearson correlation analysis demonstrated that the CT values (r =0.519, P =0.000), MA (r =0.309, P =0.000), and CI (r =0.619, P =0.000) were positively correlated with DVT, and that R time (r =-0.595, P =0.000) and K time (r =-0.445, P =0.000) were negatively correlated with DVT. ROC curve analysis revealed that the AUC of the combination of five indicators for diagnosing DVT was 0.970 (95% CI: 0.930, 1.000), with a sensitivity of 97.10% (95% CI: 0.914, 1.000) and a specificity of 84.60% (95% CI: 0.754, 0.934), exhibiting high diagnostic efficiency.Conclusions CT combined with TEG has high accuracy in evaluating DVT, and an increase in CT values as well as their combination effectively predicts the occurrence of DVT.