Objective To explore the risk factors for venous thromboembolism (VTE) occurring after surgery in ovarian cancer patients.Methods A total of 118 ovarian cancer patients at Handan First Hospital, enrolled between March 2021 and March 2024, were divided into the VTE group (n = 26) and the non-VTE group (n = 92) based on whether they developed VTE after surgery. General data between the two groups were compared. The multivariable Logistic regression was used to analyze the factors influencing the occurrence of VTE after surgery in ovarian cancer patients, based on which a nomogram was constructed. Receiver operating characteristic (ROC) curves were plotted using the occurrence of postoperative VTE as the positive outcome.Results Patients in the VTE group were older and had a higher body mass index, longer operative duration, and elevated levels of D-dimer and fibrinogen (FIB) compared with those in the non-VTE group (P < 0.05). The activated partial thromboplastin time (APTT) in the VTE group was lower than that in the non-VTE group (P < 0.05). Multivariable Logistic regression analysis showed that long operative duration [O^R = 1.080 (95% CI: 1.016, 1.148) ], high D-dimer levels [O^R = 9.919 (95% CI: 2.411, 40.809) ], and high FIB levels [O^R = 10.060 (95% CI: 1.061, 95.360) ] were risk factors for postoperative VTE in ovarian cancer patients (P < 0.05), and that short APTT [O^R = 0.252 (95% CI: 0.100, 0.630)] was a protective factor for postoperative VTE in ovarian cancer patients (P < 0.05). The results of the ROC curve demonstrated that the sensitivities of operative duration, D-dimer, FIB, APTT, and their combination for predicting postoperative VTE in ovarian cancer patients were 61.5% (95% CI: 0.406, 0.798), 80.8% (95% CI: 0.606, 0.934), 88.5% (95% CI: 0.698, 0.976), 80.8% (95% CI: 0.606, 0.934), and 96.2% (95% CI: 0.804, 0.999), respectively, with the specificities being 81.5% (95% CI: 0.721, 0.798), 94.6% (95% CI: 0.878, 0.982), 88.0% (95% CI: 0.796, 0.939), 66.3% (95% CI: 0.557, 0.758), and 94.6% (95% CI: 0.878, 0.982), and the areas under the curves being 0.748, 0.879, 0.904, 0.785, and 0.988, respectively. The combination of these indicators yielded a relatively high predictive value.Conclusion Operative duration, D-dimer, FIB, and APTT are factors affecting the occurrence of postoperative VTE in ovarian cancer patients.